p722 ferrocifen loaded lipid nanocapsules improve survival of murine xenografted-melanoma via a potentiation of apoptosis and an activation of CD8+ T lymphocytes

Metastatic melanoma is a malignant tumor with poor prognosis. Recent new therapeutics improved the survival of patients at metastatic stage. However, low response rate to immunotherapy, explained in part by resistance apoptosis, needs develop strategies. The ferrocifen family represents promising bioorganometallic molecules for treatment since they show potent anticancer properties. aim this study (i) evaluate benefits strategy involving encapsulated p722 lipid nanocapsules (LNC) B16F10 mice models and (ii) compare beneficial effects an existing therapy such as anti-CTLA4 mAb. Interestingly, LNC-p722 induces significant decrease cell viability. In vivo data shows improvement slower growth p722-loaded LNC comparison Western blots confirm that potentiates intrinsic apoptotic pathway. Treatment significantly activates CD8+ T lymphocytes compared This uncovers therapeutic prevent improve treated mice.